二、用于辅助结直肠癌的诊断
Aristotle University of Thessaloniki团队通过meta分析研究发现,粪潜血定量在15-25ug/g(75-125ng/ml)时,诊断结肠癌的灵敏度(93%)和特异度(94%)。但对于高危腺瘤,其诊断效能不足,当粪潜血定量<15ug/g(75ng/ml)时,灵敏度仅42%[3]。
【参考文献】
1. Liles, E.G., et al., Performance of a quantitative fecal immunochemical test for detecting advanced colorectal neoplasia: a prospective cohort study. BMC Cancer, 2018. 18(1): p. 509.
2. Chen, S.L., et al., Demand for Colonoscopy in Colorectal Cancer Screening Using a Quantitative Fecal Immunochemical Test and Age/Sex-Specific Thresholds for Test Positivity. Cancer Epidemiol Biomarkers Prev, 2018. 27(6): p. 704-709.
3. Katsoula, A., et al., Diagnostic Accuracy of Fecal Immunochemical Test in Patients at Increased Risk for Colorectal Cancer: A Meta-analysis. JAMA Intern Med, 2017. 177(8): p. 1110-1118.
4. Ryu, D.G., et al., Assessment of disease activity by fecal immunochemical test in ulcerative colitis. World J Gastroenterol, 2016. 22(48): p. 10617-10624.
本文整理自上海仁济检验